Let's say something like this is in the HPEL or SystemOut log or being returned by the serverStatus command.

JSAS1477W: SECURITY CLIENT/SERVER CONFIG MISMATCH:  The client security configuration (sas.client.props or outbound settings in GUI) does not support the server security configuration for the following reasons: 
     ERROR 1: JSAS0809E:  The current OID is RSA but this is not an Admin request.
     ERROR 2: JSAS0603E: The server does not support SSL/TLS, but the client is configured to require it.

Notice in this example that the mismatch is in the ${WAS_INSTALL_ROOT}/profiles/your_profile/properties/sas.client.props file, and the underlying issue is either "JSAS0809E:  The current OID is RSA but this is not an Admin request." or "JSAS0603E: The server does not support SSL/TLS, but the client is configured to require it." In this scenario, you would focus on these underlying errors.