In wrapper.conf
It almost always makes the most sense to update the HTTP / HTTPS port being used by Mule in the wrapper.conf file, instead of in AnyPoint. The -Dmule.mmc.bind.port option is used to set the HTTP port being used by Mule.
wrapper.java.additional.##=-Dmule.mmc.bind.port=8081
The -Dsd.port option is using to set the HTTPS port.
wrapper.java.additional.##=-Dsd.port=8444
In AnyPoint
The default port used by a Mule HTTP application is 8081.