Let's say something like this is being returned.

pip is configured with locations that require TLS/SSL, however the ssl module in Python is not available

I typically see this after installing Python from source using make and then attempting to list packages using pip list or install packages using pip install. I would start by using the absolute path to your Python installation and seeing if the pip list command returns the error.

]# /usr/local/bin/python3.10.2/bin/python3.10 -m pip list
Package    Version
---------- -------
pip        21.2.4
setuptools 58.1.0
WARNING: pip is configured with locations that require TLS/SSL, however the ssl module in Python is not available.
Could not fetch URL https://pypi.org/simple/pip/: There was a problem confirming the ssl certificate: HTTPSConnectionPool(host='pypi.org', port=443): Max retries exceeded with url: /simple/pip/ (Caused by SSLError("Can't connect to HTTPS URL because the SSL module is not available.")) - skipping

On a Red Hat distribution (CentOS, Fedora, Red Hat), yum list installed or dnf list installed can be used to list the installed OpenSSL packages.

• Python 3.9 can be configured with openssl version 1.0.x
• Python 3.10 and above must be configured with openssl version 1.1.x (e.g. openssl11)

]# yum list installed | grep -i openssl
Repodata is over 2 weeks old. Install yum-cron? Or run: yum makecache fast
openssl.x86_64                      1:1.0.2k-26.el7_9        @rhel-7-server-rpms
openssl-devel.x86_64                1:1.0.2k-26.el7_9        @rhel-7-server-rpms
openssl-libs.x86_64                 1:1.0.2k-26.el7_9        @rhel-7-server-rpms
openssl098e.x86_64                  0.9.8e-29.el7_2.3        @rhel-7-server-rpms
pyOpenSSL.x86_64                    0.13.1-4.el7             @rhel-7-server-rpms
xmlsec1-openssl.x86_64              1.2.20-7.el7_4           @rhel-7-server-rpms

On a Red Hat distribution (CentOS, Fedora, Red Hat), if the openssl-devel package is not installed, use yum install or dnf install to install the openssl-devel package.

dnf install openssl openssl-devel

Likewise, yum install or dnf install can be used to install the openssl version 1.1.x packages if you are installing Python version 3.10 or above.

dnf install openssl11 openssl11-devel

On a Debian distribution (Ubuntu, Mint), ensure the following packages are installed as they are required for Python 3.9 and above.

apt-get install gcc build-essential libncursesw5-dev libreadline5-dev libssl-dev libgdm-dev libbz2-dev libc6-dev libsqlite3-dev tk-dev

Use the openssl version command to confirm that the openssl CLI is working.

]# openssl version
OpenSSL 1.0.2k-fips  26 Jan 2017

Or openssl11.

]# openssl11 version
OpenSSL 1.1.1k  FIPS 25 Mar 2021

When installing Python from source, the configure script should contain a few openssl commands.

~]# grep -R Python-3.10.2 -ie 'PKG_CONFIG openssl'
Python-3.10.2/configure:                OPENSSL_LDFLAGS=`$PKG_CONFIG openssl --libs-only-L 2>/dev/null`
Python-3.10.2/configure:                    OPENSSL_LIBS=`$PKG_CONFIG openssl --libs-only-l 2>/dev/null`
Python-3.10.2/configure:                    OPENSSL_INCLUDES=`$PKG_CONFIG openssl --cflags-only-I 2>/dev/null`

For Python 3.10 and above, you may need to change this to openssl11.

sed -i 's|PKG_CONFIG openssl|PKG_CONFIG openssl11|g' /path/to/configure